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Improve Novel Therapeutics with PROTAC Discovery Solutions from Creative Biolabs

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Improve Novel Therapeutics with PROTAC Discovery Solutions from Creative Biolabs

November 20
03:21 2020
Creative Biolabs keeps the leading position as a biotechnology solution provider, which provides customized solutions to fulfill the project requirements of global clients. Regarding the novel therapeutics-proteolysis targeting chimeric (PROTAC) based molecular drug, Creative Biolabs launched services and products to expedite the research in this field.

New York, USA – November 19, 2020 – The entire health system across the world is working on developing novel therapies that are more precise, more efficient, and less toxic to normal tissues with lower side effects. The proteolysis targeting chimeric (PROTAC) based molecular drugs, a kind of protein degraders with reduced toxicity but prolonged pharmacodynamics effect, are under rapid development as a potential target therapy, especially for hard-to-treat diseases like cancer. Creative Biolabs keeps pace with this frontier technology in the field of life-science industry and is fully competent to handle customers’ PROTAC discovery projects with comprehensive “one-stop” solutions and standard products.

The molecule discovery service portfolio mainly covers 5 stages, among which the ligand design, ligand screening, and linker design are the basis of developing the desired PROTAC molecule. Based on the exclusive technological platforms, Creative Biolabs has developed a list of products that are commonly used in general research, including linkers (Bis-PEG6-acid), ligands (BRD9-Binding Moiety 1 Hydrochloride, VH 032 Amine Hydrochloride, dBET1, etc.), E3 ligase, and target proteins (Bromodomain-containing Protein 4, E3 ubiquitin-protein ligase Mdm2), which are all readily available for quick delivery. It is understandable that not all researchers have the same purposes, and Creative Biolabs provides the custom design and development services of ligand, protein, linker, etc. to satisfy various purposes.

Once a PROTAC molecule is synthesized, it should be evaluated in various aspects to verify the efficacy. Creative Biolabs has a series of PROTAC in vitro evaluation assays to monitor the specific parameters in each stage, including solubility, chemical stability, cell permeability efficacy, and target ubiquitination.

In addition to the efficacy tests, in vivo tests to evaluate the toxicity, absorption, distribution, metabolism, and excretion of a candidate PROTAC drug are indispensable. There are flexible choices of assays and tailored assay design solutions that can be accomplished in a fast turnaround cycle, enabling the customers to obtain the most comprehensive analysis report.

The one-stop services regarding the PROTAC discovery are fully supported by specialized scientists who have rich experience in this field, and all the products are accompanied by considerate after-sale service. They are offered in packages or separately, according to customers’ requests. More details can be accessed at https://www.creative-biolabs.com/protac.

Company Overview

Creative Biolabs is a leading service provider of biotechnology. Organized and operated by a group of P.h.D level scientists, the mission and belief of Creative Biolabs lie in improving novel therapies by a comprehensive list of services and high standard products that are at reasonable prices across the industry. Since establishment in 2004, dozens of projects are accomplished by the scientists and a large number of products have been delivered to global pharmaceutical partners, research institutes, and university laboratories.

Media Contact
Company Name: Creative Biolabs
Contact Person: Candy Swift
Email: Send Email
Phone: 1-631-619-7922
Country: United States
Website: https://www.creative-biolabs.com/protac